biological activity | (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity drug, it is also a popular food supplement for weight loss. (-)-hydroxy citric acid lactone is a potent ATP-citrate lyase inhibitor. (-)-Hydroxycitric acid lactone catalyzes the extracellular cleavage of citrate to oxaloacetate and acetyl-CoA, limiting the availability of acetyl-CoA units required for fatty acid synthesis. |
Animal Model:
| 1-day-old male broiler chickens |
Dosage:
| 1000, 2000, 3000 mg/kg |
Administration:
| Fed for a period of 4 weeks |
Result:
| Body weight and average daily gain (ADG) in the 2000 mg/kg and 3000 mg/kg were significantly lower. |